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1

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi, Ryo Naito, Akira Toyoshima, Noriyuki Kawano, Atsushi Ichikawa, Akiko Orita, Masaya Orita, Noritaka Hamada, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 842 KB

english, 2005

2

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

Hiroyuki Hisamichi, Ryo Naito, Akira Toyoshima, Noriyuki Kawano, Atsushi Ichikawa, Akiko Orita, Masaya Orita, Noritaka Hamada, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

3

Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors

Shinya Nagashima, Masaki Yokota, Ei-ichi Nakai, Sadao Kuromitsu, Keiko Ohga, Makoto Takeuchi, Shin-ichi Tsukamoto, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 250 KB

english, 2007

4

Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity

Takeuchi, Mitsuaki, Okamoto, Masayuki, Okamoto, Ryuji, Kinoshita, Hiroshi, Yamaguchi, Yu, Watanabe, Nobuhide

Journal:

Year:

2018

Language:

english

File:

PDF, 428 KB

english, 2018

5

Detecting early gastric cancer: Comparison between the diagnostic ability of convolutional neural networks and endoscopists

Ikenoyama, Yohei, Hirasawa, Toshiaki, Ishioka, Mitsuaki, Namikawa, Ken, Yoshimizu, Shoichi, Horiuchi, Yusuke, Ishiyama, Akiyoshi, Yoshio, Toshiyuki, Tsuchida, Tomohiro, Takeuchi, Yoshinori, Shichijo,

Journal:

Digestive Endoscopy

Year:

2020

File:

PDF, 13.42 MB

2020

6

The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell–derived endoderm

Atsushi Kubo, Yon Hui Kim, Stefan Irion, Shogo Kasuda, Mitsuaki Takeuchi, Kazuo Ohashi, Masayuki Iwano, Yoshiko Dohi, Yoshihiko Saito, Ralph Snodgrass, Gordon Keller

Journal:

Year:

2010

Language:

english

File:

PDF, 829 KB

english, 2010

7

Epstein–Barr virus-related lymphoproliferative disorder, cytomegalovirus reactivation, and varicella zoster virus encephalitis during treatment of medulloblastoma

Motoki Ohta, Takashi Taga, Akitaka Nomura, Hirofumi Kato, Tomoyuki Takano, Yoshihiro Maruo, Yoshihiro Takeuchi, Mitsuaki Ishida, Shigeru Ohta

Journal:

Journal of Medical Virology

Year:

2011

Language:

english

File:

PDF, 166 KB

english, 2011

8

Hydroperoxylated guaiane-type sesquiterpenes from Viburnum awabuki

Yoshiyasu Fukuyama, Hiroyuki Minami, Rina Ichikawa, Kumiko Takeuchi, Mitsuaki Kodama

Journal:

Year:

1996

Language:

english

File:

PDF, 406 KB

english, 1996

9

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles

Yasuhiro Yonetoku, Hirokazu Kubota, Yoshinori Okamoto, Jun Ishikawa, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 356 KB

english, 2006

10

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides

Yasuhiro Yonetoku, Hirokazu Kubota, Yoshinori Okamoto, Akira Toyoshima, Masashi Funatsu, Jun Ishikawa, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

11

Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists

Ippei Sato, Koichiro Morihira, Hiroshi Inami, Hirokazu Kubota, Tatsuaki Morokata, Keiko Suzuki, Noritaka Hamada, Yosuke Iura, Aiko Nitta, Takayuki Imaoka, Toshiya Takahashi, Makoto Takeuchi, Mitsuaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 372 KB

english, 2008

12

Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors

Shinya Nagashima, Hiroshi Nagata, Masahiro Iwata, Masaki Yokota, Hiroyuki Moritomo, Masaya Orita, Sadao Kuromitsu, Akiko Koakutsu, Keiko Ohga, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 326 KB

english, 2008

13

Discovery of potent CCR4 antagonists: Synthesis and structure–activity relationship study of 2,4-diaminoquinazolines

Kazuhiro Yokoyama, Noriko Ishikawa, Susumu Igarashi, Noriyuki Kawano, Kazuyuki Hattori, Takahiro Miyazaki, Shin-ichi Ogino, Yuzo Matsumoto, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 302 KB

english, 2008

14

Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156]

Ippei Sato, Koichiro Morihira, Hiroshi Inami, Hirokazu Kubota, Tatsuaki Morokata, Keiko Suzuki, Noritaka Hamada, Yosuke Iura, Aiko Nitta, Takayuki Imaoka, Toshiya Takahashi, Makoto Takeuchi, Mitsuaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 122 KB

english, 2008

15

Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolines

Kazuhiro Yokoyama, Noriko Ishikawa, Susumu Igarashi, Noriyuki Kawano, Naoyuki Masuda, Kazuyuki Hattori, Takahiro Miyazaki, Shin-ichi Ogino, Masaya Orita, Yuzo Matsumoto, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

16

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition

Ippei Sato, Koichiro Morihira, Hiroshi Inami, Hirokazu Kubota, Tatsuaki Morokata, Keiko Suzuki, Yosuke Iura, Aiko Nitta, Takayuki Imaoka, Toshiya Takahashi, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi T

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 292 KB

english, 2008

17

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

Yasuhiro Yonetoku, Hirokazu Kubota, Yoji Miyazaki, Yoshinori Okamoto, Masashi Funatsu, Noriko Yoshimura-Ishikawa, Jun Ishikawa, Taiji Yoshino, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 261 KB

english, 2008

18

Neovibsanines A and B, unprecedented diterpenes from Viburnum awabuki

Yoshiyasu Fukuyama, Hiroyuki Minami, Kumiko Takeuchi, Mitsuaki Kodama, Kazuyoshi Kawazu

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 229 KB

english, 1996

19

A real-time rapid eye movement sleep analyzer equipped with a portable wide-band polygraphic recorder

Mitsuaki YAMAMOTO, Norihiro KATAYAMA, Mitsuyuki NAKAO, Ryo KITAHARA, Takashi UENO, Ikuo TAKEUCHI, Noboru OHKI

Journal:

Sleep and Biological Rhythms

Year:

2003

Language:

english

File:

PDF, 82 KB

english, 2003

20

Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis

Masashi Takano, Toru Sugiyama, Nobuo Yaegashi, Mitsuaki Suzuki, Hiroshi Tsuda, Satoru Sagae, Yasuhiro Udagawa, Kazuo Kuzuya, Junzo Kigawa, Satoshi Takeuchi, Hitoshi Tsuda, Takuya Moriya, Yoshihiro Kik

Journal:

International Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 239 KB

english, 2007

21

Functional outcomes after total scapulectomy for malignant bone or soft tissue tumors in the shoulder girdle

Katsuhiro Hayashi, Mitsuaki Karita, Norio Yamamoto, Toshiharu Shirai, Hideji Nishida, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya

Journal:

International Journal of Clinical Oncology

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

22

Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats

Mitsuaki Okayama, Shusaku Hayashi, Yoko Aoi, Hikaru Nishio, Shinichi Kato, Koji Takeuchi

Journal:

Digestive Diseases and Sciences

Year:

2007

Language:

english

File:

PDF, 604 KB

english, 2007

23

An ion momentum as a novel parameter for the preparation of the magnetostrictive thin film

Koji Makita, Mitsuaki Takeuchi, Masashi Sato, Hirohisa Uchida, Yoshihito Matsumura

Journal:

Applied Surface Science

Year:

2009

Language:

english

File:

PDF, 239 KB

english, 2009

24

Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists

Ippei Sato, Koichiro Morihira, Hiroshi Inami, Hirokazu Kubota, Tatsuaki Morokata, Keiko Suzuki, Kazuki Ohno, Yosuke Iura, Aiko Nitta, Takayuki Imaoka, Toshiya Takahashi, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 753 KB

english, 2009

25

The mechanical binding strengths of Helicobacter pylori BabA and SabA adhesins using an adhesion binding assay–ELISA, and its clinical relevance in Japan

Mitsuaki Nishioka, Hiroaki Takeuchi, Sergio A. Con, Yoshio Uehara, Isao Nishimori, Toshika Okumiya, Yoshitaka Kumon, Tetsuro Sugiura

Journal:

Microbiology and Immunology

Year:

2010

Language:

english

File:

PDF, 485 KB

english, 2010

26

Diversity of Helicobacter pylori cagA and vacA Genes in Costa Rica: Its Relationship with Atrophic Gastritis and Gastric Cancer

Sergio A. Con, Hiroaki Takeuchi, Ana L. Valerín, Reinaldo Con-Wong, Gil R. Con-Chin, Vicky G. Con-Chin, Mitsuaki Nishioka, Fernando Mena, Fernando Brenes, Nobufumi Yasuda, Keijiro Araki, Tetsuro Sugiu

Journal:

Year:

2007

Language:

english

File:

PDF, 127 KB

english, 2007

27

Amelioration of caerulein-induced pancreatitis by restraint stress in the rat

Mitsumasa Abe, Shinichi Kato, Mitsuaki Okayama, Shoji Mitsufuji, Koji Takeuchi

Journal:

Inflammopharmacology

Year:

2002

Language:

english

File:

PDF, 285 KB

english, 2002

28

Production of d-amino acid oxidase from Aspergillus sojae

Mamoru Wakayama, Yuka Takeuchi, Katsuyuki Tasaka, Kenji Sakai, Mitsuaki Moriguchi

Journal:

Journal of Fermentation and Bioengineering

Year:

1996

Language:

english

File:

PDF, 409 KB

english, 1996

29

Synthesis and structure–activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Kenji Negoro, Yasuhiro Yonetoku, Tatsuya Maruyama, Shigeru Yoshida, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

30

Discovery of novel and potent CRTH2 antagonists

Shinji Ito, Tadashi Terasaka, Tatsuya Zenkoh, Hiroshi Matsuda, Hisashi Hayashida, Hiroshi Nagata, Yoshimasa Imamura, Miki Kobayashi, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

31

Mitral regurgitation resulting from the consecutive multiple perforations by infective endocarditis mimicking the isolated anterior mitral cleft

Tomofumi Takaya, Yoshio Takeuchi, Masashi Okamoto, Katsuya Hata, Yoichi Kijima, Kenji Nakajima, Tomoyuki Kita, Mitsuaki Ito, Hideto Nakajima, Rie Takaoka, Takuo Nomura, Kazuhiko Iwahashi, Seinosuke Ka

Journal:

Journal of Cardiology

Year:

2008

Language:

english

File:

PDF, 604 KB

english, 2008

32

The usefulness of transesophageal echocardiographic observation during chemotherapy for cardiac metastasis of non-Hodgkin lymphoma complicated with left ventricular diastolic collapse

Tomofumi Takaya, Yoshio Takeuchi, Hideto Nakajima, Saori Nishiki-Kosaka, Katsuya Hata, Yoichi Kijima, Tomoyuki Kita, Mitsuaki Ito, Masashi Okamoto, Yuji Nishikawa, Toshihiko Seo, Rie Takaoka, Kensuke

Journal:

Journal of Cardiology

Year:

2009

Language:

english

File:

PDF, 645 KB

english, 2009

33

Relationship of IL-8 production and the CagA status in AGS cells infected with Helicobacter pylori exposed to low pH and activating transcription factor 3 (ATF3)

Yanan Zhang, Hiroaki Takeuchi, Mitsuaki Nishioka, Norihito Morimoto, Mikio Kamioka, Yoshitaka Kumon, Tetsuro Sugiura

Journal:

Microbiological Research

Year:

2009

Language:

english

File:

PDF, 619 KB

english, 2009

34

Chemical erosion and sputtering of solid surfaces with liquid cluster ions

Gikan H. Takaoka, Hiromichi Ryuto, Yudai Kubo, Mitsuaki Takeuchi

Journal:

Surface and Coatings Technology

Year:

2011

Language:

english

File:

PDF, 566 KB

english, 2011

35

Micro-patterning of Si(100) surfaces by ethanol cluster ion beams

Gikan H. Takaoka, Hiromichi Ryuto, Ryosuke Ozaki, Hiroshi Mukai, Mitsuaki Takeuchi

Journal:

Surface and Coatings Technology

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

36

Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

Nitta, Aiko, Iura, Yosuke, Inoue, Hideki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, To

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 967 KB

english, 2012

37

Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists

Aiko Nitta, Yosuke Iura, Hiroki Tomioka, Ippei Sato, Koichiro Morihira, Hirokazu Kubota, Tatsuaki Morokata, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto, Takayuki Imaoka, Toshiya Takahashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

38

Effects of oblique deposition on magnetostrictive characteristics of TbFe2 films formed by ion plating

Konosuke Muramatsu, Tomoko O. Yamaki, Noriyoshi Matsuoka, Mitsuaki Takeuchi, Yoshihito Matsumura, Hirohisa Uchida

Journal:

Journal of Alloys and Compounds

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

39

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists

Kenji Negoro, Yasuhiro Yonetoku, Hana Misawa-Mukai, Wataru Hamaguchi, Tatsuya Maruyama, Shigeru Yoshida, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 750 KB

english, 2012

40

Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists

Kenji Negoro, Yasuhiro Yonetoku, Ayako Moritomo, Masahiko Hayakawa, Kazuhiko Iikubo, Shigeru Yoshida, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

41

Development of ionic liquid ion source with porous emitter for surface modification

Takeuchi, Mitsuaki, Hamaguchi, Takuya, Ryuto, Hiromichi, Takaoka, Gikan H.

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

2013

Language:

english

File:

PDF, 937 KB

english, 2013

42

Interaction between water cluster ions and mica surface

Ryuto, Hiromichi, Ohmura, Yuki, Nakagawa, Minoru, Takeuchi, Mitsuaki, Takaoka, Gikan H.

Journal:

Journal of Vacuum Science & Technology A Vacuum Surfaces and Films

Year:

2014

Language:

english

File:

PDF, 407 KB

english, 2014

43

Beneficial influence of restraint stress on caerulein-induced pancreatitis in rats: Role of endogenous glucocorticoids

Abe, Mitsumasa, Kato, Shinichi, Okayama, Mitsuaki, Aihara, Eitaro, Mitsufuji, Shoji, Takeuchi, Koji, Okanoue, Takeshi

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

44

To Correspondents.

Ryuto, Hiromichi, Ichihashi, Gaku, Takeuchi, Mitsuaki, Takaoka, Gikan H.

Journal:

Year:

1862

Language:

english

File:

PDF, 226 KB

english, 1862

45

Irradiation effects of water cluster ion beam on PMMA surface

Ryuto, Hiromichi, Ichihashi, Gaku, Takeuchi, Mitsuaki, Takaoka, Gikan H.

Journal:

Year:

2013

Language:

english

File:

PDF, 354 KB

english, 2013

46

Irradiation effect of gas-hydrate cluster ions on solid surfaces

Takaoka, Gikan H., Ryuto, Hiromichi, Takeuchi, Mitsuaki, Kobayashi, Hiroki

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

47

Surface processing using water cluster ion beams

Takaoka, Gikan H., Ryuto, Hiromichi, Takeuchi, Mitsuaki, Ichihashi, Gaku

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

2013

Language:

english

File:

PDF, 890 KB

english, 2013

48

Production and irradiation of ionic liquid cluster ions

Takaoka, Gikan H., Takeuchi, Mitsuaki, Ryuto, Hiromichi, Ueda, Ryo

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

2013

Language:

english

File:

PDF, 615 KB

english, 2013

49

Mucosal irritative and healing impairment effects of bisphosphonates in rat stomachs

Kanastu, Kenji, Okayama, Mitsuaki, Kato, Shimichi, Takeuchi, Koji

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 508 KB

english, 2003

50

Irradiation of ionic liquid ion beams on silicon and glass substrates

Takeuchi, Mitsuaki, Hamaguchi, Takuya, Ryuto, Hiromichi, Takaoka, Gikan H.

Journal:

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013